Guided tissue organization and disease modeling in a kidney tubule array

Obesity and Kidney Disease

The rise in the prevalence of chronic kidney disease (CKD) and an increase in the prevalence of obesity in parallel in the recent years is a great concern. CKD increases the rate of cardiovascular disease (CVD) and development of end-stage renal disease, and leads to premature death. Although no direct causality link between obesity and CKD can yet be established, this appears highly probable. ...

Failed Tubule Recovery, AKI-CKD Transition, and Kidney Disease Progression.

The transition of AKI to CKD has major clinical significance. As reviewed here, recent studies show that a subpopulation of dedifferentiated, proliferating tubules recovering from AKI undergo pathologic growth arrest, fail to redifferentiate, and become atrophic. These abnormal tubules exhibit persistent, unregulated, and progressively increasing profibrotic signaling along multiple pathways. P...

معرفی درمان ضایعات استخوانی توسط روش guided tissue regeneration

چکیده ندارد.

Non-albuminuric Diabetic Kidney Disease in Diabetic Patients: A Review

Introduction: The constantly increasing incidence of type 2 diabetes, probably due to obesity and sedentary life, has led to the increased incidence of macro- and microvascular diabetic complications such as nephropathy. Despite the prompt efforts to develop effective treatments for diabetes and slow the progression of its complications, it is still reported as the most common cause of chronic ...

Kidney organoids for disease modeling